Hi there :-)
10mm Alu is a good starting point, as in most people totally underestimate the power of modern machines, and that might be a good option depending on the type of machine you want to build. There are many grades of aluminium so make sure you choose a good quality grade such as 6061 or 6082. There is also 7075 but its much more expensive, though much stiffer, so save that for when you do version 2.
The alternative is to use a wear steel like Hardox, about 3-4mm thick. Mild Steel is no good these days, but Stainless 314 is an option though very expensive. Calling up your local waterjet/plasma cutting company and having a chat and you should be able to source a sheet to suit your needs; K-Cut seems to be the go-too for many builders. Unless you have an angle grinder you won;t be able to cut or machine the Hardox yourself (unless you have the right tools) so most people have their base CNC'd from Hardox, with all the mounting holes for the other components done at the same time, and work from there.




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